Mitogen-Activated Protein Kinase Kinase Inhibitor
Information
- Drug Name
- Mitogen-Activated Protein Kinase Kinase Inhibitor
- Description
- Entry(CIViC)
- 7
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| skin melanoma |
BRAF p.Asp634Ala (p.D634A) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asp634Ala (p.D634A) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
E |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 20141835 | Detail |
| skin melanoma |
BRAF p.Lys523Met (p.K523M) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Lys523Met (p.K523M) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
E |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 20141835 | Detail |
| ovarian serous carcinoma | BRAF BRAF-CUL1 | C |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 26324360 | Detail |
| melanoma |
BRAF p.Val640Asp (p.V640D) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Asp (p.V640D) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 31580757 | Detail |
| melanoma | BRAF APC BRAF APC | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 31580757 | Detail |
| melanoma | BRAF G469 BRAF G469 | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 31580757 | Detail |
| melanoma | BRAF A598V BRAF A598V | C |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 31580757 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Preclinical study in melanoma cell lines. Inactivi... | BRAF |
BRAF p.Asp634Ala (p.D634A) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asp634Ala (p.D634A) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
Sensitivity | true | CIViC Evidence | detail |
| Preclinical study in melanoma cell lines. Inactivi... | BRAF |
BRAF p.Lys523Met (p.K523M) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Lys523Met (p.K523M) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
Sensitivity | true | CIViC Evidence | detail |
| One patient with low-grade serous ovarian cancer h... | BRAF | BRAF BRAF-CUL1 | Sensitivity | true | CIViC Evidence | detail |
| In a retrospective study from 20 institutes in 4 c... | BRAF |
BRAF p.Val640Asp (p.V640D) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Asp (p.V640D) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
Sensitivity | true | CIViC Evidence | detail |
| In a retrospective study from 20 institutes in 4 c... | BRAF | BRAF APC BRAF APC | Sensitivity | true | CIViC Evidence | detail |
| In a retrospective study from 20 institutes in 4 c... | BRAF | BRAF G469 BRAF G469 | Sensitivity | true | CIViC Evidence | detail |
| In a retrospective study from 20 institutes in 4 c... | BRAF | BRAF A598V BRAF A598V | Sensitivity | false | CIViC Evidence | detail |